Point of view tells you where to start and stop a scene or a story. The essential questions:
- Where do the important events start and stop for the POV character?
- Which character has the most interesting perspective on that part of the story?
If you're starting with the victim, the story starts when the victim becomes aware that something unusual is happening. If you're starting with the murderer, the story starts with the decision to commit the murder or with the murder itself. If you're starting with the detective, the story starts with the detective learning about the case.
The character with the most interesting POV and the most important character in the story are not necessarily the same: Sherlock Holmes is the protagonist, but Watson is the better POV character because Watson's a more complex character than Holmes, who is brilliant, but broken and monomaniacal in a way that's more interesting when seen from the POV of Watson, who loves and admires him.